ESR1 抗原（重组蛋白）

Background:

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.

Tags:

His tag C-Terminus, GST tag N-Terminus

Expression system:

Escherichia coli

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Gene Accession:

BC128573

Swissprot:

P03372

Synonyms:

ER; ESR; Era; ESRA; ESTRR; NR3A1

Full name:

estrogen receptor 1