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技术规格
Background:
SRGAP1 (Slit-robo Rho GTPase activating protein 1), also known as ARHGAP13 (Rho GTPase activating protein 13), functions as a GTPase-activating protein for Cdc42 and Rho A. Expressed in kidney, testis, lung and brain, SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner.
Applications:
ELISA, IHC
Name of antibody:
SRGAP1
Immunogen:
Synthetic peptide of human SRGAP1
Full name:
SLIT-ROBO Rho GTPase activating protein 1
Synonyms:
ARHGAP13
SwissProt:
Q7Z6B7
ELISA Recommended dilution:
2000-5000
IHC positive control:
Human liver cancer
IHC Recommend dilution:
25-100