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Background:
The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications:
ELISA, WB, IHC
Name of antibody:
SPAG4
Immunogen:
Synthetic peptide of human SPAG4
Full name:
sperm associated antigen 4
Synonyms:
SUN4; CT127
SwissProt:
Q9NPE6
ELISA Recommended dilution:
5000-10000
IHC positive control:
Human cervical cancer and Human lung cancer
IHC Recommend dilution:
25-100
WB Predicted band size:
48 kDa
WB Positive control:
Human bladder transitional cell carcinoma grade 2-3 tissue lysate
WB Recommended dilution:
200-1000