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Background:
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.
Applications:
WB
Name of antibody:
TLK1
Immunogen:
Synthesized peptide derived from internal of human TLK1.
Full name:
tousled-like kinase 1
Synonyms:
PKU-beta
SwissProt:
Q9UKI8
WB Predicted band size:
87 kDa
WB Positive control:
Rat brain tissue and NIH/3T3 cells lysates
WB Recommended dilution:
500-3000