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IHC Recommend dilution:
25-100
IHC positive control:
Human liver cancer
ELISA Recommended dilution:
2000-5000
SwissProt:
Q8WZ73
Synonyms:
CARP2; FRING; CARP-2; RNF189; RNF34L; RIFIFYLIN
Full name:
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
Immunogen:
Fusion protein of human RFFL
Name of antibody:
RFFL
Applications:
ELISA, IHC
Background:
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation.