兔抗PDZD3多克隆抗体

Background:

Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).

Applications:

ELISA, IHC

Name of antibody:

PDZD3

Immunogen:

Fusion protein of human PDZD3

Full name:

PDZ domain containing 3

Synonyms:

IKEPP; PDZK2; NHERF4

SwissProt:

Q86UT5

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human cervical cancer and Human tonsil

IHC Recommend dilution:

25-100