兔抗RNF217多克隆抗体

Background:

This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants.

Applications:

ELISA, IHC

Name of antibody:

RNF217

Immunogen:

Synthetic peptide of human RNF217

Full name:

ring finger protein 217

Synonyms:

OSTL; IBRDC1; C6orf172; dJ84N20.1

SwissProt:

Q8TC41

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil

IHC Recommend dilution:

20-100