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技术规格
Background:
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications:
ELISA, IHC
Name of antibody:
ROR1
Immunogen:
Synthetic peptide of human ROR1
Full name:
receptor tyrosine kinase-like orphan receptor 1
Synonyms:
NTRKR1; dJ537F10.1
SwissProt:
Q01973
ELISA Recommended dilution:
2000-5000
IHC positive control:
Human lung cancer and Human prostate cancer
IHC Recommend dilution:
25-100