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Background:
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
Applications:
WB, IHC
Name of antibody:
RELA(Ab-311)
Immunogen:
Peptide sequence around aa.309~313 (F-K-S-I-M) derived from Human RELA.
Full name:
v-rel avian reticuloendotheliosis viral oncogene homolog A
Synonyms:
p65; NFKB3
SwissProt:
Q04206
IHC positive control:
Human breast carcinoma tissue
IHC Recommend dilution:
50-100
WB Predicted band size:
60 kDa
WB Positive control:
Hela and HL60 cell lysates
WB Recommended dilution:
500-1000