兔抗PDIA3多克隆抗体

Background:

Secretory proteins translocate into the endoplasmic reticulum (ER) after their synthesis where they are post-translationally modified and properly folded. To reach their native conformation, many secretory proteins require the formation of intra- or inter-molecular disulfide bonds. This process is called oxidative protein folding. Disulfide isomerase (PDI) has two thioredoxin homology domains and catalyzes the formation and isomerization of these disulfide bonds. Other ER resident proteins that possess the thioredoxin homology domains, including endoplasmic reticulum stress protein 57 (ERp57), constitute the PDI family. ERp57 interacts with calnexin and calreticulin and is suggested to play a role in the isomerization of disulfide bonds on certain glycoproteins.

Applications:

WB

Name of antibody:

PDIA3

Immunogen:

Fusion protein of human PDIA3

Full name:

protein disulfide isomerase family A, member 3

Synonyms：

PDIA3; ER60; ERp57; ERp60; ERp61; GRP57; GRP58; HsT17083; P58; PI-PLC

SwissProt:

P30101

WB Predicted band size:

57 kDa

WB Positive control:

HT-29, PC-3, HepG2, NIH3T3, U2OS, HeLa, Jurkat and Raw264.7 cells

WB Recommended dilution:

500-2000