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英文名称： ZNF217 Antigen (Recombinant Protein)
别 名： zinc finger protein 217; ZABC1
储 存： 冷冻（-20℃）
相关类别： 抗原
概述
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Fusion protein corresponding to N terminal 200 amino acids of human ZNF217 |
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Full name: |
zinc finger protein 217 |
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Synonyms: |
ZABC1 |
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Swissprot: |
O75362 |
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Gene Accession: |
BC113427 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
ZNF217, also known as ZABC1, is a zinc finger protein belonging to the Krüppel C2H2-type zinc-finger protein family. It localizes to the nucleus and may play a role in transcriptional repression of a variety of genes through the recruitment of co-repressor complexes containing proteins such as CtBP, HDAC1 and HDAC2. In addition, ZNF217 participates in cell differentiation and appears to function as an oncogene. Expression of ZNF217 is amplified in various tumors and overexpression of the protein can attenuate apoptotic signals and lead to epithelial cell immortalization.Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. |
