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英文名称： USP5 Antigen (Recombinant Protein)
别 名： ubiquitin specific peptidase 5 (isopeptidase T); ISOT
储 存： 冷冻（-20℃）
相关类别： 抗原
概述
|
Fusion protein corresponding to C terminal 200 amino acids of human USP5 |
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Full name: |
ubiquitin specific peptidase 5 (isopeptidase T) |
|
Synonyms: |
ISOT |
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Swissprot: |
P45974 |
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Gene Accession: |
BC004889 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]). |
