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英文名称: SHPK Antigen (Recombinant Protein)
别 名: sedoheptulokinase; SHK; CARKL
储 存: 冷冻(-20℃)
相关类别 抗原
Fusion protein corresponding to a region derived from 279-478 amino acids of human SHPK |
Full name: |
sedoheptulokinase |
Synonyms: |
SHK; CARKL |
Swissprot: |
Q9UHJ6 |
Gene Accession: |
BC020543 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. |