PPM1B抗原（重组蛋白）

Full name:

protein phosphatase, Mg2+/Mn2+ dependent 1B

Synonyms:

PP2CB; PP2CBETA; PP2C-beta; PPC2BETAX; PP2C-beta-X

Swissprot:

O75688

Gene Accession:

BC012002

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.