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英文名称:DIABLO Antigen (Recombinant Protein)
别 名: SMAC; SMAC3; DFNA64; DIABLO-S
储 存: 冷冻(-20℃)
相关类别: 抗原
概述
Fusion protein corresponding to a region derived from 56-239 amino acids of human DIABLO |
Full name: |
Diablo, IAP-binding mitochondrial protein |
Synonyms: |
SMAC; SMAC3; DFNA64; DIABLO-S |
Swissprot: |
Q9NR28 |
Gene Accession: |
BC011909 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein. Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed. |