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英文名称: ATF6B Antigen (Recombinant Protein)
别 名: activating transcription factor 6 beta; G13; CREBL1; CREB-RP
储 存: 冷冻(-20℃)
相关类别: 抗原
概述
Fusion protein corresponding to a region derived from 2-200 amino acids of human ATF6B |
Full name: |
activating transcription factor 6 beta |
Synonyms: |
G13; CREBL1; CREB-RP |
Swissprot: |
Q99941 |
Gene Accession: |
BC008394 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. |