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英文名称： SPDL1 Antigen (Recombinant Protein)
别 名： CCDC99
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述
|
Fusion protein corresponding to C terminal 250 amino acids of human SPDL1 |
技术规格
|
Full name: |
Spindle apparatus coiled-coil protein 1 |
|
Synonyms: |
CCDC99 |
|
Swissprot: |
Q96EA4 |
|
Gene Accession: |
BC012568 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect. |
