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英文名称： SPDEF Antigen (Recombinant Protein)
别 名： PDEF, bA375E1.3, RP11-375E1__A.3
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述
|
Fusion protein corresponding to a region derived from 129-332 amino acids of human SPDEF |
技术规格
|
Full name: |
SAM pointed domain containing ets transcription factor |
|
Synonyms: |
PDEF, bA375E1.3, RP11-375E1__A.3 |
|
Swissprot: |
O95238 |
|
Gene Accession: |
BC021299 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
