RPS6KB1抗原（重组蛋白）

Full name:

ribosomal protein S6 kinase, 70kDa, polypeptide 1

Synonyms:

S6K, PS6K, S6K1, STK14A, p70-S6K, p70-alpha, p70(S6K)-alpha

Swissprot:

P23443

Gene Accession:

BC053365

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.