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Fusion protein corresponding to C terminal 300 amino acids of human RB1 |
技术规格
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Full name: |
retinoblastoma 1 |
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Synonyms: |
RB; pRb; OSRC; pp110; p105-Rb |
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Swissprot: |
P06400 |
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Gene Accession: |
BC039060 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma |
