兔抗VAV1多克隆抗体

Background:

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Applications:

WB

Name of antibody:

VAV1

Immunogen:

Synthetic peptide of human VAV1 (Ab-174)

Full name:

vav 1 guanine nucleotide exchange factor

Synonyms：

VAV

SwissProt:

P15498

WB Predicted band size:

98 kDa

WB Positive control:

Jurkat cells

WB Recommended dilution:

500-1000