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技术规格
Background: |
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. |
Applications: |
ELISA, WB, IHC |
Name of antibody: |
UPF1 |
Immunogen: |
Synthetic peptide of human UPF1 |
Full name: |
UPF1 RNA helicase and ATPase |
Synonyms: |
HUPF1; NORF1; RENT1; smg-2; pNORF1 |
SwissProt: |
Q92900 |
ELISA Recommended dilution: |
1000-5000 |
IHC positive control: |
Human liver cancer and Human thyroid cancer |
IHC Recommend dilution: |
50-200 |
WB Predicted band size: |
124 kDa |
WB Positive control: |
Raji cells |
WB Recommended dilution: |
200-1000 |