兔抗UPF1多克隆抗体

Background:

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.

Applications:

ELISA, WB, IHC

Name of antibody:

UPF1

Immunogen:

Synthetic peptide of human UPF1

Full name:

UPF1 RNA helicase and ATPase

Synonyms:

HUPF1; NORF1; RENT1; smg-2; pNORF1

SwissProt:

Q92900

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human liver cancer and Human thyroid cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

124 kDa

WB Positive control:

Raji cells

WB Recommended dilution:

200-1000