兔抗UGT1A4多克隆抗体

Background:

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.

Applications:

ELISA, IHC

Name of antibody:

UGT1A4

Immunogen:

Synthetic peptide of human UGT1A4

Full name:

UDP glucuronosyltransferase family 1 member A4

Synonyms:

UDPGT; UGT1D; UGT-1D; UGT1.4; HUG-BR2; UGT1-04; UGT1A4S; UDPGT 1-4

SwissProt:

P22310

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human brain

IHC Recommend dilution:

20-100