兔抗GAB2(Ab-159) 多克隆抗体

Background:

Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.

Applications:

WB, IHC

Name of antibody:

GAB2(Ab-159)

Immunogen:

Synthesized non-phosphopeptide derived from human GRB2 around the phosphorylation site of serine 159 (K-S-S(p)-A-P).

Full name:

GRB2-associated binding protein 2

Synonyms：

KIAA0571

SwissProt:

Q9UQC2

IHC positive control:

Human colon carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

74 kDa

WB Positive control:

COS cells lysate

WB Recommended dilution:

500-3000