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Background:
RASGEF1A (RasGEF domain family, member 1A) is a 481 amino acid guanine-nucleotide exchange factor (GEF) for H-Ras, K-Ras, and N-Ras. RASGEF1A may also play a role in cell migration. RASFEG1A is highly expressed in spinal chord and brain and contains one N-terminal Ras-GEF domain and one Ras-GEF domain. The gene that encodes RASGEF1A maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome.
Applications:
ELISA, IHC
Name of antibody:
RASGEF1A
Immunogen:
Fusion protein of human RASGEF1A
Full name:
RasGEF domain family, member 1A
Synonyms:
CG4853
SwissProt:
Q8N9B8
ELISA Recommended dilution:
2000-5000
IHC positive control:
Human breast cancer and human thyroid cancer
IHC Recommend dilution:
20-100