兔抗MMP12多克隆抗体

Background:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin.

Applications:

ELISA, WB, IHC

Name of antibody:

MMP12

Immunogen:

Fusion protein of human MMP12

Full name:

matrix metallopeptidase 12 (macrophage elastase)

Synonyms:

ME; HME; MME; MMP-12

SwissProt:

P39900

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer and human esophagus cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

54 kDa

WB Positive control:

293T cell lysate

WB Recommended dilution:

200-1000