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中文名称：DOK1抗原（重组蛋白）
英文名称： DOK1 Antigen (Recombinant Protein)
储 存： 冷冻（-20℃）
相关类别： 抗原
概述
|
Fusion protein corresponding to C terminal 300 amino acids of human DOK1 |
技术规格
|
Full name: |
docking protein 1, 62kDa (downstream of tyrosine kinase 1) |
|
Synonyms: |
P62DOK |
|
Swissprot: |
Q99704 |
|
Gene Accession: |
BC114440 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. |
