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DNAJA1抗原(重组蛋白)

品牌:纪宁生物

货号:JN7170

规格: 100ug

联系方式:021-66980655

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产品详情

中文名称: DNAJA1 抗原(重组蛋白)

英文名称: DNAJA1 Antigen (Recombinant Protein)

别      名: DnaJ (Hsp40) homolog, subfamily A, member 1; DJ-2; DjA1; HDJ2; HSDJ; HSJ2; HSPF4; NEDD7; hDJ-2

储      存: 冷冻(-20℃)

相关类别: 抗原

概述

Fusion protein corresponding to a region derived from 206-397 amino acids of human DNAJA1


技术规格


Full name:

DnaJ (Hsp40) homolog, subfamily A, member 1

Synonyms:

DJ-2; DjA1; HDJ2; HSDJ; HSJ2; HSPF4; NEDD7; hDJ-2

Swissprot:

P31689

Gene Accession:

BC008182

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.

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