兔抗P4HB多克隆抗体

Background:

During their synthesis, secretory proteins translocate into the endoplasmic reticulum (ER) where they are post-translationally modified and properly folded. To reach their native conformation, many secretory proteins require the formation of intra- or inter-molecular disulfide bonds. This process is called oxidative protein folding. Protein disulfide isomerase (PDI) catalyzes the formation and isomerization of these disulfide bonds. Studies on mechanisms of oxidative folding suggest that molecular oxygen oxidizes the ER-protein Ero1, which in turn oxidizes PDI through disulfide exchange. This event is then followed by PDI-catalyzed disulfide bond formation in folding proteins.

Applications:

WB

Name of antibody:

P4HB

Immunogen:

Fusion protein of human P4HB

Full name:

prolyl 4-hydroxylase, beta polypeptide

Synonyms：

P4HB; DSI; ERBA2L; GIT; P4Hbeta; PDI; PDIA1; PHDB; PO4DB; PO4HB; PROHB

SwissProt:

P07237

WB Predicted band size:

57 kDa

WB Positive control:

THP1, SW620, 6T-CEM, NIH3T3 and RAW264.7 cells, liver and kidney tissue

WB Recommended dilution:

500-2000