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英文名称： POU5F1 Antigen (Recombinant Protein)
别 名： OCT3, OCT4, OTF3, OTF4, OTF-3, Oct-3, Oct-4
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述
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Fusion protein corresponding to a region derived from 1-150 amino acids of human POU5F1 |
技术规格
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Full name: |
POU class 5 homeobox 1 |
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Synonyms: |
OCT3, OCT4, OTF3, OTF4, OTF-3, Oct-3, Oct-4 |
|
Swissprot: |
Q01860 |
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Gene Accession: |
BC117435 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6;22)(p21;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. |
