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中文名称: PEG10抗原(重组蛋白)
英文名称: PEG10 Antigen (Recombinant Protein)
别 名: EDR, HB-1, Mar2, MEF3L, Mart2, RGAG3
储 存: 冷冻(-20℃)
相关类别: 抗原
概 述
Fusion protein corresponding to C terminal 250 amino acids of human PEG10 |
技术规格
Full name: |
paternally expressed 10 |
Synonyms: |
EDR, HB-1, Mar2, MEF3L, Mart2, RGAG3 |
Swissprot: |
Q86TG7 |
Gene Accession: |
BC050659 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas. |