兔抗GJB6多克隆抗体

Background:

Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.

Applications:

ELISA, WB, IHC

Name of antibody:

GJB6

Immunogen:

Synthetic peptide of human GJB6

Full name:

Gap junction beta-6 protein

Synonyms：

ED2, EDH, HED, CX30, DFNA3, DFNA3B, DFNB1B

SwissProt:

O95452

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human brain and Human liver cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

30 kDa

WB Positive control:

293T and Hela cells

WB Recommended dilution:

500-2000